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Control Of Covid-19 In The US Is Mostly Bad News, But Highly Effective Vaccines And Declining Fatality Rates Are Good News

As Covid-19 cases, hospitalizations, and deaths are increasing in most US states, compliance with recommended control measures seems to be decreasing. Over 2,000 deaths were recorded in one day before Thanksgiving and the CDC warning to avoid travel over the holiday went unheeded at many airports.

More Deaths

According to the Institute for Health Metrics and Evaluation (IHME), the US has now recorded over 263,000 deaths and it projects an additional 208,000 deaths by March 1 for a total  approaching half a million (471,000) caused by SARS-CoV-2. This prediction assumes that states will re-impose social distancing mandates as risk increases beyond 8 daily deaths per million. Otherwise, the final death count by March 1 could reach 658,000. For now, IHME estimates that daily deaths will reach a peak of over 2,500 per day in mid-January and may even climb to 5,000 per day if restrictions are eased rather than tightened.

Masks

The IMHE continues to suggest that increasing mask use to 95% could save many lives, and as many as 65,000 by March 1. However mask-wearing behavior defined as always using a mask when leaving home seems to have peaked at 68%, according to IHME and right now it projects no increase in that percentage. However, President-elect Biden has called for mask mandates at the state level in his revised Covid-19 control plan (see article in this issue), and this policy emphasis could save thousands of additional lives if widely adopted.

Good News

On the good news side, the IHME estimates that the infection fatality rate (IFR) has declined over time by an estimated 30% since last spring. This may be due to the use of drugs and learning how to better care for patients over time. Data suggest the IFR varies also as a function of the level of obesity in a community and the age structure of that population. The preliminary reports from randomized controlled trials of highly effective SARS-CoV-2 vaccines has been called nothing less than a “scientific triumph” and one achieved in record time.

Rush No Problem

According to Arnold Monto, University of Michigan epidemiologist who chairs the Food and Drug Administration’s Covid-19 vaccine advisory committee, the fact that the vaccine was rushed should be ignored. He told local media in Michigan  “the rush happened because of extra funds and extra attention that was given. The platform, the way these vaccines were produced, was already there.” 


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