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Canadian Epidemiologist Called “Thoughtful Pioneer” For His Million Death Study

Prabhat Jha, an Indian-Canadian epidemiologist, was profiled recently by 52 Insights. The online magazine publishes weekly interviews with leaders, innovators and pioneers in a variety of fields ranging from science and politics to popular culture. Prabhat Jha was chosen for his work on the Million Death Study. According to magazine founder Ari Stein, “We like thoughtful pioneers such as Prabhat Jha and hugely disruptive projects such as the Million Death Study.”

Sobering Statistics

The interview leads with a pair of sobering statistics. “Only 3% of individuals that die worldwide have an official cause of death certificate. More specifically, in India, a country of over a billion people, 80% of deaths take place outside the healthcare system.” Without information on causes of death, countries are hindered in developing strategies to address premature mortality or in assuring the appropriateness of existing strategies.

Grandmother Interview

In the most revealing moment of the interview, Jha recounts a visit to his grandmother’s village shortly after his grandfather’s passing. A medical student at the time, he asked her to tell him how his grandfather had died. “From her description, I could tell that he probably had a stroke. I was able to convey that to my mother and grandmother and it brought them a bit of closure. Only later did I look back and realize that listening to my grandmother was something that had worked, and it might work on a larger level.”

Million Death Study

That realization led Jha to initiate the ambitious Million Death Study. The study, conducted from 1998 – 2014, sought to quantify the causes of premature mortality in more than a million previously undocumented deaths in India. “India is an amazing laboratory of understanding major patterns of diseases and their risk factors,” Jha said in the interview.

Methods

Partnering with the Registrar General of India’s existing Sample Registration System, the Million Death Study monitored deaths occurring in nationally representative Indian households. Trained surveyors visited the households twice a year. After noting a death, an in-person interview was conducted with a close family member using the verbal autopsy method. Two trained physicians then used the written information to assign a cause of death. In the event of a disagreement of diagnosis, a senior physician was brought in.

Impact

In the interview, Jha asserts the study demonstrated the need for the Indian government to take tobacco more seriously and prompted an increase in taxes on tobacco. Additionally, the work estimated that nearly 200,000 deaths occur annually from malaria, an increase by more than an order of magnitude from the 15,000 estimated by the WHO. Conversely, HIV deaths were only a quarter of what was predicted. These differences have also triggered changes in funding.

Criticism

The study has received criticism that verbal autopsy cannot diagnose the cause of death with complete certainty. However, in the case of malaria, Jha and his colleagues look for additional factors such as seasonality and the degree to which malaria is reported in the area to bolster the diagnoses.

Global Idea

Jha goes on to explain in the interview how India is just one example of how this problem plays out globally, and that a future where everyone dies in hospital is a long way off. In the meantime, his “diagnosis for the world’s problems on mortality is very simple. Collect a random sample of all the deaths in every major population, enumerated through verbal autopsy.”

The biggest obstacle to this? Sustained funding. “Anything really important in global health is never a matter of doing things in the next year or two. You have to think in terms of a decade. And that’s where you see progress.”

Prabhat Jha is the founding director of the Centre for Global Health Research, the Inaugural University of Toronto Endowed Professor in Disease Control, Canada Research Chair at the Dalla Lana School of Public Health, co-investigator of the Disease Control Priorities Network, and a Bill and Melinda Gates Foundation advisor on HIV/AIDS control in India.

To read the interview in more detail, visit:  https://tinyurl.com/zabndse

 


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